DIETARY SATURATED AND MONOSATURATED FATS PROTECT AGAINST ACUTE ACETAMINOPHEN HEPATOTOXICITY. Nasýtené a mononenasýtené tuky v strave majú protektívny účinok pri akútnej hepatotoxicite acetaminofénu. In conclusion, the present study confirms that drug-induced liver injury is promoted by substitution of PUFA from rich sources such as corn oil for fatty acids derived from beef tallow and olive oil. However, it is unlikely that the protection afforded by these dietary fats is effectively with PUFA for esterification into phospholipids. No change occurred in composition of SFA in our study. Instead, a major shift between linoleic acid and oleic acid occurred. Our data suggest that diets with high MUFA protect against the hepatotoxicity of acetaminophen by affecting the fatty acid composition of membrane phospholipids, thereby reducing susceptibility to free radical damage. A clear demonstration that the fatty acids present in beef tallow and olive oil help reduce this kind of injury could lead to better understanding of what constitutes a healthy diet. These findings help understand the effects of type of dietary fat on the nutritional management of drug-induced hepatotoxicity. Other types of dietary fats and/or chronic drug-induced hepatotoxicity need to be investigated for future study.
Posted on: Sun, 21 Jul 2013 17:14:59 +0000
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